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Designing an antimicrobial and cell-adhesive multilayer

How to counteract nosocomial infections associated with medical devices in hospitals

Erschienen am 08.07.2015, 1. Auflage 2015
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Bibliografische Daten
ISBN/EAN: 9783838133430
Sprache: Englisch
Umfang: 132 S.
Format (T/L/B): 0.8 x 22 x 15 cm
Einband: kartoniertes Buch

Beschreibung

In this work surface modifications were developed that bear cell-adhesive as well as antimicrobial properties. Fast cell adhesion and wound healing is desired for biomaterials since otherwise the material would be recognized as a foreign body and infectious bacteria could enter the cavity between material and tissue. Plasma polymerization was used as the deposition technique since a broad range of materials can be coated independent of their composition. As a cell-adhesive coating plasma polymerized allylamine was chosen since it is cell-friendly and offers a platform for wet chemical modifications such as grafting of fibronectin. Furthermore, it serves as a barrier layer for zinc and silver containing sub-layers that exhibit antimicrobial properties due to the release of zinc and silver. The layer systems were spectroscopically and microscopically investigated. Cell-adhesive and antimicrobial properties were tested with various types of cells and bacteria.

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Autorenportrait

studied Chemistry in Germany at the Technical University of Kaiserslautern and the Johannes-Gutenberg University of Mainz. He pursued his PhD studies on biomaterials and plasma polymerization at the Max Planck Institut for Polymer Research and was working with international partners on EU-projects to publish and patent his research.