In 1866, with the country barely recovered from the Civil War, new war breaks out on the western frontier - a clash of cultures between a young, ambitious nation and the Native tribes who have lived on the land for centuries. Colonel Henry Carrington arrives in Wyoming's Powder River Valley to lead the US Army in defending the opening of a new road for gold miners and settlers. Red Cloud, one of the Lakota's most respected chiefs, and Crazy Horse, a young but visionary warrior, understand full well the implications of this invasion. For the Lakota, the stakes are their home, their culture, their lives.