The volume includes 75 papers which were presented at the Third International Conference on Intracerebral Hemorrhage, held in Rancho Mirage, California, in March 2010. The topics treated include animal models, pathophysiology of cerebral hemorrhage, experimental treatment for cerebral hemorrhage, cerebral hemorrhage clinical manifestations, prognosis of cerebral hemorrhage, and clinical management. The articles represent the recent advances in hemorrhagic brain injury research presented by highly respected laboratories around the world.

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Cerebral hemorrhage animal models: Q. Ma, N. Khatibi, H. Chen, J. Tang, J. H. Zhang: History of Preclinical Models of Intracerebral Hemorrhage. - A. Manaenko, H. Chen, J. H. Zhang, J. Tang Comparison of different preclinical models of intracerebral hemorrhage. - H. Chen, J. H. Zhang: Cerebral amyloid angiopathy-related microhemorrhages in Alzheimer's disease: a review of investigative animal models. - B. Orakcioglu, M. Kentar, Y. Uozumi, E. Santos, P. Schiebel, A. Unterberg, O.W. Sakowitz: Multiparametric characterisation of the perihemorrhagic zone in a porcine model of lobar ICH. - J. Tang, J. Ai, R. Loch Macdonald: Developing a model of chronic subdural hematoma. - Y. Tada, Y. Kanematsu, M. Kanematsu, Y. Nuki, E. I Liang, K. Wada, H. Makino, T. Hashimoto: A mouse model of intracranial aneurysma¿'technical considerations. - T. Lekic, R. P. Ostrowski, H. Suzuki, A. Manaenko, W. Rolland, N. Fathali, J. Tang, J. H. Zhang: The postpartum period of pregnancy worsens brain injury and functional outcome after cerebellar hemorrhage in rats. - T. Tsubokawa, H. Joshita, Y. Shiokawa, H. Miyazaki: Hyperglycemia and hemorrhagic transformation of cerebral infarction: a macroscopic hemorrhagic transformation rat model. - Y. Xing, X. Jiang, Y. Yang, G. Xi: Hemorrhagic transformation induced by acute hyperglycemia in a rat model of transient focal ischemia. -T. Lekic, A. Manaenko, W. Rolland, J. Tang, J. H. Zhang: A novel preclinical model of germinal matrix hemorrhage using neonatal rats. Pathophysiology of cerebral hemorrhage: J. Lok, W. Leung, S. Murphy, W. Butler, N. Noviski, E. H. Lo: Intracranial hemorrhage - mechanisms of secondary brain injury. - R.F. Keep, G. Xi, Y. Hua, J. Xiang: Clot formation, vascular repair and hematoma resolution after ICH, a coordinating role for thrombin?. - D.-Z. Liu, F. R Sharp: The dual role of src kinases in intracerebral hemorrhage. - H. Kim, H. Su, S. Weinsheimer, L. Pawlikowska, W. L. Young: Brain arteriovenous malformation pathogenesis: a response-to-injury paradigm. - N. Fathali, N. H. Khatibi, R. P. Ostrowski, J. H. Zhang: The evolving landscape of neuroinflammation after neonatal hypoxia-ischemia. - F. Zhao, S. Song, W. Liu, R. F. Keep, G. Xi, Y. Hua: Red blood cell lysis and brain tissue-type transglutaminase upregulation in a hippocampal model of intracerebral hemorrhage. - X. Zhao, S. Song, G. Sun, J. Zhang, R. Strong, L. Zhang, J. C. Grotta, J. Aronowski: Cytoprotective role of haptoglobin in brain after experimental intracerebral hemorrhage. - Y. Gong, Y. He, Y. Gu, R. F. Keep, G. Xi, Y. Hua: Effects of aging on autophagy after experimental intracerebral hemorrhage Z. Ye, Q. Xie, G. Xi, R. Keep, Y. Hua: Effects of gender on heart injury after intracerebral hemorrhage in rats Y. Gu, Y. Hua, Y. He, L. Wang, H. Hu, R. F. Keep, G. Xi: Iron accumulation and DNA damage in a pig model of intracerebral hemorrhage H. Suzuki, T. Sozen, Y. Hasegawa, W. Chen, K. Kanamaru, W. Taki, J. H. Zhang: Subarachnoid hemorrhage causes pulmonary endothelial cell apoptosis and neurogenic pulmonary edema in mice Y. He, Y. Hua, R. F. Keep, W. Liu, M. M. Wang, G. Xi: Hemoglobin expression in neurons and glia after intracerebral hemorrhage Experimental treatment for cerebral hemorrhage P. R. Gigante, G. Appelboom, B. Y. Hwang, R. M. Haque, M. L. Yeh, A. Ducruet, C. P. Kellner, J. Gorski, S. E. Keesecker, E. Sander Connolly, Jr.: Isoflurane preconditioning affords functional neuroprotection in a murine model of intracerebral hemorrhage R. Ayer, V. Jadhav, T. Sugawara, J.H. Zhang: The neuroprotective effects of cyclooxygenase-2 inhibition in a mouse model of aneurysmal subarachnoid hemorrhage J. Tong, J. M. Latzman, J. Rauch, D. S. Zagzag, J. H. Huang, U. Samadani: Sonic hedgehog agonist fails to induce neural stem cell precursors in a porcine model of experimental intracranial hemorrhageA. Manaenko, T. Lekic, J. H. Zhang, J. Tang: NC1900, An arginine vasopressin analogue, ...