This book, Vol. 6 in the series Topics in Bone Biology, deals with bone develop ment from growth to mineralization. Understanding tissue dev- opment involves combining embryological and histological information with the increasing knowledge from molecular and genetic studies. In each developmental stage, some genes are expressed and others silenced. Disease, especially disease progression, also is characterized by changes in gene expression that then are transmitted to daughter cells. In both situations, the choreography of gene expression and partial or complete silencing often are the result of the interaction between the genome and the epi- nome, i.e., between a very stable set of structures and rapidly changing environmental factors. Chapter 1, by OConnor, Farach-Carson, and Schanen, is an overview of the feld and of topics discussed in greater detail in subsequent chapters. After discussing bone development in terms of intramembranous and en- chondral ossifcation, the chapter describes gene expression in osteoblasts and osteoclasts, bone cell coupling, and the regulatory effects of steroid h- mones. Primary genetic defects that lead to various bone diseases Marfans syndrome, Pagets disease, and juvenile osteoporosis, among others are analyzed. The chapter ends with a section on the epigenetic regulation of bone development, including methylation, histone modifcations, and imprinting. This chapter, like all others, has an extensive bibliography and fgures to illustrate principal points.

Genetic and Epigenetic Aspects of Bone Development.- Tissue Interactions in Long Bone Development.- The Epiphyseal Growth Plate.- Hedgehog Signaling in Growth Plate and Bone Development.- Role of microRNA in Skeleton Development.- FGF/FGFR Signaling in Skeletal Dysplasias.- The Role of Hypoxia-Induced Factors.- BMP Signaling in Skeletogenesis.- Wnt Signaling in Bone Development.- Development of the Craniofacial Complex.- Dentin and Bone: Similar Collagenous Mineralized Tissues.- Evolution of Bone Proteins.- Osteogenesis Imperfecta.- Fibrodysplasia Ossificans Progressiva: Developmental Implications of a Novel Metamorphogene.- Bone-Mineral Homeostasis and Associated Pathologies.- Interrelationship Between Bone and Other Tissues: BrainBone Axis and Bone-Adipo Axis.- Mechanobiology of Bone Development and Computational Simulations.