This book presents a clear and precise discussion of the biochemistry of eukaryotic cells, particularly those of mammalian tissues, relates biochemical events at a cellular level to the subsequent physiological processes in the whole animal, and cites examples of abnormal biochemical processes in human disease. The organization and content are tied together to provide students with the complete picture of biochemistry and how it relates to human diseases.

Preface. Acknowledgments. PART I: STRUCTURE OF MACROMOLECULES. 1. Eukaryotic Cell Structure 2. DNA and RNA: Composition and Structure 3. Proteins I: Composition and Structure PART II: TRANSMISSION OF INFORMATION. 4. DNA Replication, Recombination, and Repair 5. RNA: Transcription and RNA Processing 6. Protein Synthesis: Translation and Posttranslational Modifications 7. Recombinant DNA and Biotechnology 8. Regulation of Gene Expression 9. Proteins II: Structure-Function Relationships in Protein Families 10. Enzymes: Classification, Kinetics, and Control 11. The Cytochromes P450 and Nitric Oxide Synthases 12. Biological Membranes: Structure, Receptors, and Solute Transport 13. Fundamentals of Signal Transduction 14. Bioenergetics, Mitochondria, and Oxidative Metabolism 15. Carbohydrate Metabolism I: Major Metabolic Pathways and Their Control 16. Carbohydrate Metabolism II: Special Pathways and Glycoconjugates 17. Lipid Metabolism I: Synthesis, Storage, and Utilization of Fatty Acids and Triacylglycerols 18. Lipid Metabolism II: Pathways of Metabolism of Special Lipids 19. Amino Acid and Heme Metabolism 20. Purine and Pyrimidine Nucleotide Metabolism 21. Metabolic Interrelationships 22. Biochemistry of Hormones 23. Molecular Cell Biology 24. Cell Cycle, Programmed Cell Death, and Cancer 25. Digestion and Absorption of Basic Nutritional Constituents 26. Vitamins and Minerals: Requirements and Function 27. Macronutrients: Metabolic Effects and Health Implications Appendix: Review of Organic Chemistry Glossary Index.